Target：AK1C4

Fields：Primary bile acid biosynthesis;Steroid hormone biosynthesis;Metabolic pathways;Chemical carcinogenesis - reactive oxygen species

Gene Name：AKR1C4 CHDR

Protein Name：Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (3-alpha-HSD1) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.50) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4

Human Gene Id：1109

Human Swiss Prot No：P17516

Immunogen：Synthesized peptide derived from human protein . at AA range: 1-80

Specificity：AK1C4 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：35kD

Background： This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H.,catalytic activity:Chlordecone alcohol + NADP(+) = chlordecone + NADPH.,function:Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.,polymorphism:The allele with Cys-145/Val-311 shows a three- to five-fold decrease in catalytic efficiency for xenobiotic and steroidal substrates compared to the Ser-145/Leu-311 allele.,PTM:The N-terminus is blocked.,similarity:Belongs to the aldo/keto reductase family.,subunit:

Subcellular Location：Cytoplasm, cytosol .

Expression：Liver specific.