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S6A19 Polyclonal Antibody
S6A19 Polyclonal Antibody
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S6A19 Polyclonal Antibody
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经销商客户: ¥214.5
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商品描述

商品属性

Target:S6A19

Fields:Protein digestion and absorption;Mineral absorption

Gene Name:SLC6A19 B0AT1

Protein Name:Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1)

Human Gene Id:340024

Human Swiss Prot No:Q695T7

Mouse Swiss Prot No:Q9D687

Rat Swiss Prot No:Q2A865

Immunogen:Synthesized peptide derived from part region of human protein

Specificity:S6A19 Polyclonal Antibody detects endogenous levels of protein.

Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:WB 1:500-2000 ELISA 1:5000-20000

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD):69kD

Background: This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. [provided by RefSeq, Jul 2008],

Function:disease:Defects in SLC6A19 are a cause of Hartnup disorder (HND) [MIM:234500]. HND is an autosomal recessive abnormality of renal and gastrointestinal neutral amino acid transport noted for its clinical variability. First described in 1956, HND is characterized by increases in the urinary and intestinal excretion of neutral amino acids. Individuals with typical Hartnup aminoaciduria may be asymptomatic, some develop a photosensitive pellagra-like rash, attacks of cerebellar ataxia and other neurological or psychiatric features. Although the definition of HND was originally based on clinical and biochemical abnormalities, its marked clinical heterogeneity has led to it being known as a disorder with a consistent pathognomonic neutral hyperaminoaciduria.,function:Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kid

Subcellular Location:Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Colocalizes with ACE2 on the apical membrane of cells lining villi of the jejunum, ileum and on kidney proximal tubules. .

Expression:Robust expression in kidney and small intestine, with minimal expression in pancreas (PubMed:18424768, PubMed:15286787). Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus, heart or lung.

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