Target：AK1

Fields：Purine metabolism;Thiamine metabolism;Metabolic pathways;Nucleotide metabolism;Biosynthesis of cofactors

Gene Name：AK1

Protein Name：Adenylate kinase isoenzyme 1

Human Gene Id：203

Human Swiss Prot No：P00568

Mouse Gene Id：11636

Mouse Swiss Prot No：Q9R0Y5

Rat Gene Id：24183

Rat Swiss Prot No：P39069

Immunogen：The antiserum was produced against synthesized peptide derived from human KAD1 . AA range:101-150

Specificity：AK1 Polyclonal Antibody detects endogenous levels of AK1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AK1;Adenylate kinase isoenzyme 1;AK 1;ATP-AMP transphosphorylase 1;Myokinase

Molecular Weight(Da)：22kD

Background：adenylate kinase 1(AK1) Homo sapiens This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],

Function：catalytic activity:ATP + AMP = 2 ADP.,disease:Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency [MIM:612631].,function:Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.,online information:Adenylate kinase entry,polymorphism:This enzyme represents the most common of at least five alleles.,similarity:Belongs to the adenylate kinase family.,subunit:Monomer.,

Subcellular Location：Cytoplasm.

Expression： Chondrosarcoma Lung Metastasis,Colon,Fetal brain cortex,Retina,Skeletal muscle,Synovial mem