Target：SENP3

Gene Name：SENP3

Protein Name：Sentrin-specific protease 3

Human Gene Id：26168

Human Swiss Prot No：Q9H4L4

Mouse Gene Id：80886

Mouse Swiss Prot No：Q9EP97

Immunogen：The antiserum was produced against synthesized peptide derived from human SENP3. AA range:10-59

Specificity：SENP3 Polyclonal Antibody detects endogenous levels of SENP3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SENP3;SSP3;SUSP3;Sentrin-specific protease 3;SUMO-1-specific protease 3;Sentrin/SUMO-specific protease SENP3

Observed Band(KD)：80kD

Background： The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009],

Function：function:Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability.,similarity:Belongs to the peptidase C48 family.,subunit:Binds to UBL1 and SMT3H1.,

Subcellular Location：Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm . Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). .

Expression： Epithelium,Lymph,Melanoma,Uterus,