Target：SENP5

Gene Name：SENP5

Protein Name：Sentrin-specific protease 5

Human Gene Id：205564

Human Swiss Prot No：Q96HI0

Mouse Gene Id：320213

Mouse Swiss Prot No：Q6NXL6

Immunogen：The antiserum was produced against synthesized peptide derived from human SENP5. AA range:651-700

Specificity：SENP5 Polyclonal Antibody detects endogenous levels of SENP5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SENP5;FKSG45;Sentrin-specific protease 5;Sentrin/SUMO-specific protease SENP5

Observed Band(KD)：86kD

Background： The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009],

Function：function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.,similarity:Belongs to the peptidase C48 family.,

Subcellular Location：Nucleus, nucleolus .

Expression： Placenta,Testis,