Target：SENP2

Fields：Nucleocytoplasmic transport;Wnt signaling pathway

Gene Name：SENP2

Protein Name：Sentrin-specific protease 2

Human Gene Id：59343

Human Swiss Prot No：Q9HC62

Mouse Gene Id：75826

Mouse Swiss Prot No：Q91ZX6

Rat Gene Id：78973

Rat Swiss Prot No：Q9EQE1

Immunogen：The antiserum was produced against synthesized peptide derived from human SENP2. AA range:481-530

Specificity：SENP2 Polyclonal Antibody detects endogenous levels of SENP2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SENP2;KIAA1331;Sentrin-specific protease 2;Axam2;SMT3-specific isopeptidase 2;Smt3ip2;Sentrin/SUMO-specific protease SENP2

Observed Band(KD)：68kD

Background： SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004],

Function：domain:The N-terminus is necessary and sufficient for nuclear envelope targeting.,function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.,PTM:Polyubiquitinated; which leads to proteasomal degradation.,similarity:Belongs to the peptidase C48 family.,subcellular location:Shuttles between cytoplasm and nucleus.,subunit:Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus.,

Subcellular Location：Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . Cytoplasm . Shuttles between cytoplasm and nucleus. .

Expression： Brain,Fetal brain,Melanoma,Teratocarcinoma,