Target：Sck

Fields：EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;ErbB signaling pathway;Ras signaling pathway;Chemokine signaling pathway;Phospholipase D signaling pathway;VEGF signaling pathway;Focal adhesion;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Insulin signaling pathway;Estrogen signaling pathway;Prolactin signaling pathway;Relaxin signaling pathway;Growth hormone synthesis, secretion and action;Alcoholism;Bacterial invasion of epithelial cells;Glioma;Chronic myeloid leukemia;Breast cancer;Hepatocellular carcinoma;Gastric cancer

Gene Name：SHC2

Protein Name：SHC-transforming protein 2

Human Gene Id：25759

Human Swiss Prot No：P98077

Mouse Swiss Prot No：Q8BMC3

Rat Gene Id：314612

Rat Swiss Prot No：O70142

Immunogen：The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310

Specificity：Sck Polyclonal Antibody detects endogenous levels of Sck protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SHC2;SCK;SHCB;SHC-transforming protein 2;Protein Sck;SHC-transforming protein B;Src homology 2 domain-containing-transforming protein C2;SH2 domain protein C2

Observed Band(KD)：59kD

Background：domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,

Function：domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,

Subcellular Location：intracellular,cytosol,plasma membrane,

Expression：Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.