Target：SCML2

Gene Name：SCML2

Protein Name：Sex comb on midleg-like protein 2

Human Gene Id：10389

Human Swiss Prot No：Q9UQR0

Immunogen：Synthesized peptide derived from the Internal region of human SCML2.

Specificity：SCML2 Polyclonal Antibody detects endogenous levels of SCML2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SCML2;Sex comb on midleg-like protein 2

Observed Band(KD)：77kD

Background： This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010],

Function：function:Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SCM family.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 MBT repeats.,tissue specificity:Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.,

Subcellular Location：Nucleus .

Expression：Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.