Target：AIRP

Fields：Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nucleotide metabolism

Gene Name：NT5C1B

Protein Name：Cytosolic 5'-nucleotidase 1B

Human Gene Id：93034

Human Swiss Prot No：Q96P26

Mouse Swiss Prot No：Q91YE9

Immunogen：The antiserum was produced against synthesized peptide derived from human NT5C1B. AA range:171-220

Specificity：AIRP Polyclonal Antibody detects endogenous levels of AIRP protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NT5C1B;AIRP;FKSG85;Cytosolic 5'-nucleotidase 1B;cN1B;Autoimmune infertility-related protein;Cytosolic 5'-nucleotidase IB;cN-IB

Observed Band(KD)：69kD

Background： Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008],

Function：catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Magnesium.,enzyme regulation:Activated by ADP.,function:Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels.,function:Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.,similarity:Belongs to the 5'-nucleotidase type 3 family.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,tissue specificity:Expressed in brain, kidney, pancreas and placenta.,tissue specificity:Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung.,

Subcellular Location：Cytoplasm .

Expression：Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung.