Target：S29A2

Fields：Alcoholism

Gene Name：SLC29A2 DER12 ENT2 HNP36

Protein Name：Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equil

Human Gene Id：3177

Human Swiss Prot No：Q14542

Mouse Swiss Prot No：Q61672

Rat Swiss Prot No：O54699

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：S29A2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：50kD

Background： The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008],

Function：function:Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.,induction:By platelet derived growth factor (PDGF) and fibroblast growth factor (FGF).,similarity:Belongs to the SLC29A transporter family.,tissue specificity:Expressed in placenta, brain, heart and ovarian tissues.,

Subcellular Location：Basolateral cell membrane ; Multi-pass membrane protein . Nucleus membrane ; Multi-pass membrane protein . Localized at the basolateral cell membrane in polarized MDCK cells.

Expression：Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.