Target：LASP-1
Gene Name：LASP1
Protein Name：LIM and SH3 domain protein 1
Human Gene Id：3927
Human Swiss Prot No：Q14847
Mouse Gene Id：16796
Mouse Swiss Prot No：Q61792
Rat Gene Id：29278
Rat Swiss Prot No：Q99MZ8
Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human LASP1. AA range:51-100
Specificity：LASP-1 Polyclonal Antibody detects endogenous levels of LASP-1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：LASP1;MLN50;LIM and SH3 domain protein 1;LASP-1;Metastatic lymph node gene 50 protein;MLN 50
Observed Band(KD)：28kD
Background： This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012],
Function：function:Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.,PTM:Phosphorylated.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 nebulin repeats.,subcellular location:Associated with the F-actin rich cortical cytoskeleton.,subunit:Interacts with F-actin.,
Subcellular Location：Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Associated with the F-actin rich cortical cytoskeleton. .
Expression： Epithelium,Liver,Mammary carcinoma,Platelet,Skin,T-cell,
