Target：LASS4

Fields：Sphingolipid metabolism;Metabolic pathways;Sphingolipid signaling pathway

Gene Name：CERS4

Protein Name：Ceramide synthase 4

Human Gene Id：79603

Human Swiss Prot No：Q9HA82

Mouse Swiss Prot No：Q9D6J1

Immunogen：The antiserum was produced against synthesized peptide derived from human LASS4. AA range:41-90

Specificity：LASS4 Polyclonal Antibody detects endogenous levels of LASS4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CERS4;LASS4;Ceramide synthase 4;CerS4;LAG1 longevity assurance homolog 4

Observed Band(KD)：46kD

Background：function:May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain.,

Function：function:May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain.,

Subcellular Location：Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Expression： Cerebellum,Embryo,Lung,