Target：CNK2

Gene Name：CNKSR2

Protein Name：Connector enhancer of kinase suppressor of ras 2

Human Gene Id：22866

Human Swiss Prot No：Q8WXI2

Mouse Gene Id：245684

Mouse Swiss Prot No：Q80YA9

Rat Gene Id：59322

Rat Swiss Prot No：Q9Z1T4

Immunogen：The antiserum was produced against synthesized peptide derived from human CNKR2. AA range:641-690

Specificity：CNK2 Polyclonal Antibody detects endogenous levels of CNK2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CNKSR2;CNK2;KIAA0902;KSR2;Connector enhancer of kinase suppressor of ras 2;Connector enhancer of KSR 2;CNK homolog protein 2;CNK2

Observed Band(KD)：117kD

Background： This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],

Function：function:May function as an adapter protein or regulator of Ras signaling pathways.,PTM:Phosphorylated on tyrosine.,similarity:Belongs to the CNKSR family.,similarity:Contains 1 CRIC domain.,similarity:Contains 1 DUF1170 domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subunit:Interacts with RAF1, RAB2L and RAL GTPase proteins.,

Subcellular Location：Cytoplasm. Membrane; Peripheral membrane protein.

Expression： Brain,Fetal brain,