Target：CNK1

Gene Name：CNKSR1

Protein Name：Connector enhancer of kinase suppressor of ras 1

Human Gene Id：10256

Human Swiss Prot No：Q969H4

Immunogen：The antiserum was produced against synthesized peptide derived from human CNKR1. AA range:491-540

Specificity：CNK1 Polyclonal Antibody detects endogenous levels of CNK1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CNKSR1;CNK1;Connector enhancer of kinase suppressor of ras 1;Connector enhancer of KSR 1;CNK homolog protein 1;CNK1;hCNK1;Connector enhancer of KSR-like

Observed Band(KD)：80kD

Background： This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Function：function:May function as an adapter protein or regulator of Ras signaling pathways.,PTM:Phosphorylated on tyrosine.,similarity:Belongs to the CNKSR family.,similarity:Contains 1 CRIC domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subunit:Interacts with RHO and RALGDS.,

Subcellular Location：Cytoplasm . Membrane ; Peripheral membrane protein .

Expression： Brain,Epithelium,Kidney,Liver,Neuroepithelium,Place