Target：CNDP1

Fields：Arginine and proline metabolism;Histidine metabolism;beta-Alanine metabolism;Metabolic pathways

Gene Name：CNDP1 CN1 CPGL2 UNQ1915/PRO4380

Protein Name：Beta-Ala-His dipeptidase (EC 3.4.13.20) (CNDP dipeptidase 1) (Carnosine dipeptidase 1) (Glutamate carboxypeptidase-like protein 2) (Serum carnosinase)

Human Gene Id：84735

Human Swiss Prot No：Q96KN2

Mouse Swiss Prot No：Q8BUG2

Rat Swiss Prot No：Q66HG3

Immunogen：Synthesized peptide derived from human protein . at AA range: 330-410

Specificity：CNDP1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：55kD

Background： This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.,cofactor:Binds 2 zinc ions per subunit.,disease:Deficiency of CNDP1 may be the cause of homocarnosinosis.,disease:Diabetic patients with the CNDP1 Mannheim allele are less susceptible for nephropathy.,enzyme regulation:Inhibited by the metal chelator 1,10-o-phenantrolin. The inhibitory concentration 50% (IC(50)) is 5 uM.,polymorphism:The number of trinucleotide (CTG) repeat varies among different alleles leading to insertion of Leu residues in the signal peptide. The allele with 5 leucines (as shown in the reference entry) is known as the Mannheim allele.,similarity:Belongs to the peptidase M20A family.,subunit:Homodimer.,tissue specificity:Expressed in adult nervous central system.,

Subcellular Location：Secreted .

Expression：Found in serum and adult nervous central system. Absent in serum from patients with homocarnosinosis.