Target：CD74

Fields：Antigen processing and presentation;Tuberculosis;Herpes simplex virus 1 infection

Gene Name：CD74

Protein Name：HLA class II histocompatibility antigen gamma chain

Human Gene Id：972

Human Swiss Prot No：P04233

Mouse Swiss Prot No：P04441

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human CD74. AA range:161-210

Specificity：CD74 Polyclonal Antibody detects endogenous levels of CD74 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CD74;DHLAG;HLA class II histocompatibility antigen gamma chain;HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain;Ii;p33;CD74

Observed Band(KD)：33kD

Background： The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],

Function：function:Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Nonamer composed of three alpha/beta/gamma heterotrimers.,

Subcellular Location：Cell membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; [Isoform p41]: Late endosome . Lysosome .

Expression：[Isoform p41]: In B cells, represents 10% of total CD74 expression. ; [Isoform p33]: In B cells, represents 70% of total CD74 expression.