Target：CD73

Fields：Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nucleotide metabolism

Gene Name：NT5E

Protein Name：5'-nucleotidase

Human Gene Id：4907

Human Swiss Prot No：P21589

Mouse Swiss Prot No：Q61503

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human NT5E. AA range:431-480

Specificity：CD73 Polyclonal Antibody detects endogenous levels of CD73 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NT5E;NT5;NTE;5'-nucleotidase;5'-NT;Ecto-5'-nucleotidase;CD73

Observed Band(KD)：68kD

Background： The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011],

Function：catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Zinc.,disease:There is a decrease in the activity of NT5 in B-cell chronic lymphocytic leukemia.,function:Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.,similarity:Belongs to the 5'-nucleotidase family.,subunit:Homodimer; disulfide-linked.,

Subcellular Location：Cell membrane ; Lipid-anchor, GPI-anchor .

Expression： Leukocyte,Liver,Placenta,Skin,