Target：CD64
Fields：Phagosome;Osteoclast differentiation;Neutrophil extracellular trap formation;Hematopoietic cell lineage;Fc gamma R-mediated phagocytosis;Leishmaniasis;Staphylococcus aureus infection;Tuberculosis;Transcriptional misregulation in cancer;Acute myeloid leukemia;Systemic lupus erythematosus
Gene Name：FCGR1A FCG1 FCGR1 IGFR1
Protein Name：High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Human Gene Id：2209
Human Swiss Prot No：P12314
Mouse Gene Id：14129
Mouse Swiss Prot No：P26151
Immunogen：Synthetic peptide from human protein at AA range: 230-280
Specificity：The antibody detects endogenous CD64
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I;Fc-gamma RI;FcRI;Fc-gamma RIA;FcgammaRIa;CD antigen CD64)
Observed Band(KD)：45kD
Background： This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008],
Function：function:High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.,online information:FCGR1A mutation db,PTM:N-glycosylated.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the immunoglobulin superfamily. FCGR1 family.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Stabilized at the cell membrane through interaction with FCER1G.,subunit:Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL.,tissue specificity:Monocyte/macrophage specific.,
Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Stabilized at the cell membrane through interaction with FCER1G.
Expression：Monocyte/macrophage specific.
