Target：CD6

Fields：Cell adhesion molecules

Gene Name：CD6

Protein Name：T-cell differentiation antigen CD6

Human Gene Id：923

Human Swiss Prot No：P30203

Mouse Swiss Prot No：Q61003

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human CD6. AA range:361-410

Specificity：CD6 Polyclonal Antibody detects endogenous levels of CD6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CD6;T-cell differentiation antigen CD6;T12;TP120;CD6

Observed Band(KD)：73kD

Background： This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Function：function:Involved in cell adhesion. Binds to CD166.,PTM:After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.,PTM:Contains intrachain disulfide bond(s).,similarity:Contains 3 SRCR domains.,tissue specificity:Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938). .; [Soluble CD6]: Secreted . The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain. .

Expression：Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.