Target：BRD2

Gene Name：BRD2 KIAA9001 RING3

Protein Name：Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein)

Human Gene Id：6046

Human Swiss Prot No：P25440

Mouse Swiss Prot No：Q7JJ13

Rat Swiss Prot No：Q6MGA9

Immunogen：Synthesized peptide derived from part region of human protein AA range: 300-350

Specificity：BRD2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：88kD

Background： This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010],

Function：domain:One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'.,function:May play a role in spermatogenesis or folliculogenesis.,similarity:Contains 1 ET domain.,similarity:Contains 2 bromo domains.,subunit:Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13'.,

Subcellular Location：Nucleus . Detected on chromatin and nucleosomes.

Expression： Bone marrow,Epithelium,PNS,T-cell,Testis,