Target：BRCAA1

Gene Name：ARID4B

Protein Name：AT-rich interactive domain-containing protein 4B

Human Gene Id：51742

Human Swiss Prot No：Q4LE39

Mouse Gene Id：94246

Mouse Swiss Prot No：A2CG63

Rat Gene Id：84481

Rat Swiss Prot No：Q9JKB5

Immunogen：The antiserum was produced against synthesized peptide derived from human BRCAA1. AA range:761-810

Specificity：BRCAA1 Polyclonal Antibody detects endogenous levels of BRCAA1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ARID4B;BRCAA1;RBBP1L1;RBP1L1;SAP180;AT-rich interactive domain-containing protein 4B;ARID domain-containing protein 4B;180 kDa Sin3-associated polypeptide;Sin3-associated polypeptide p180;Breast cancer-associated antigen BRCAA1;Hi

Observed Band(KD)：148kD

Background： This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008],

Function：domain:The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.,domain:The C-terminus mediates interaction with mSin3A corepressor complex.,domain:The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Contains 1 ARID domain.,subcellular location:Cytoplasmic in breast cancer cells.,subunit:Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.,tissue specificity:Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.,

Subcellular Location：Nucleus . Cytoplasm . Cytoplasmic in breast cancer cells. .

Expression：Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.