Target：BMP-3A
Fields：Cytokine-cytokine receptor interaction
Gene Name：BMP3
Protein Name：Bone morphogenetic protein 3
Human Gene Id：651
Human Swiss Prot No：P12645
Mouse Swiss Prot No：Q8BHE5
Immunogen：The antiserum was produced against synthesized peptide derived from human BMP3. AA range:281-330
Specificity：BMP-3A Polyclonal Antibody detects endogenous levels of BMP-3A protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：BMP3;BMP3A;Bone morphogenetic protein 3;BMP-3;Bone morphogenetic protein 3A;BMP-3A;Osteogenin
Observed Band(KD)：55kD
Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016],
Function：function:Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.,induction:Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.,online information:Bone morphogenetic protein 3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in adult and fetal cartilage.,
Subcellular Location：Secreted.
Expression：Expressed in adult and fetal cartilage.
