Target：BMP2K

Fields：Transcriptional misregulation in cancer

Gene Name：BMP2K BIKE HRIHFB2017

Protein Name：BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1)

Human Gene Id：55589

Human Swiss Prot No：Q9NSY1

Mouse Swiss Prot No：Q91Z96

Immunogen：Synthesized peptide derived from human protein . at AA range: 740-820

Specificity：BMP2K Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：127kD

Background： This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May be involved in osteoblast differentiation.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,

Subcellular Location：Nucleus .

Expression： Brain,Epithelium,Ovary,Synovial membrane tissue,Testis,Thyroid,