Target：MCT4

Fields：Central carbon metabolism in cancer

Gene Name：SLC16A3

Protein Name：Monocarboxylate transporter 4

Human Gene Id：9123

Human Swiss Prot No：O15427

Mouse Gene Id：80879

Mouse Swiss Prot No：P57787

Rat Gene Id：80878

Rat Swiss Prot No：O35910

Immunogen：The antiserum was produced against synthesized peptide derived from human MOT4. AA range:233-282

Specificity：MCT4 Polyclonal Antibody detects endogenous levels of MCT4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC16A3;MCT4;Monocarboxylate transporter 4;MCT 4;Solute carrier family 16 member 3

Observed Band(KD)：49kD

Background： Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008],

Function：function:Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.,similarity:Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.,tissue specificity:Highly expressed in skeletal muscle.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Highly expressed in skeletal muscle.