Target：BMP-15

Fields：Cytokine-cytokine receptor interaction;Ovarian steroidogenesis

Gene Name：BMP15

Protein Name：Bone morphogenetic protein 15

Human Gene Id：9210

Human Swiss Prot No：O95972

Mouse Gene Id：12155

Mouse Swiss Prot No：Q9Z0L4

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human BMP15. AA range:291-340

Specificity：BMP-15 Polyclonal Antibody detects endogenous levels of BMP-15 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC: 100-300.WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BMP15;GDF9B;Bone morphogenetic protein 15;BMP-15;Growth/differentiation factor 9B;GDF-9B

Observed Band(KD)：45kD

Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016],

Function：disease:Defects in BMP15 are the cause of ovarian dysgenesis 2 (ODG2) [MIM:300510]; also called X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Hypergonadotropic ovarian failure is a heterogeneous disorder that, in the most severe forms, is a result of ovarian dysgenesis (OD) or ovarian defective development. OD accounts for about half of the cases of primary amenorrhea.,function:May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.,miscellaneous:The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked.,

Subcellular Location：Secreted.