Target：Arylsulfatase A
Fields：Sphingolipid metabolism;Metabolic pathways;Lysosome
Gene Name：ARSA
Protein Name：Arylsulfatase A
Human Gene Id：410
Human Swiss Prot No：P15289
Mouse Gene Id：11883
Mouse Swiss Prot No：P50428
Immunogen：The antiserum was produced against synthesized peptide derived from human ARSA. AA range:251-300
Specificity：Arylsulfatase A Polyclonal Antibody detects endogenous levels of Arylsulfatase A protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ARSA;Arylsulfatase A;ASA;Cerebroside-sulfatase
Observed Band(KD)：54kD
Background： The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010],
Function：catalytic activity:A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate.,cofactor:Binds 1 magnesium ion per subunit.,disease:Arylsulfatase A activity is defective in multiple sulfatase deficiency (MSD) [MIM:272200]. MSD is a disorder characterized by decreased activity of all known sulfatases. MSD is due to defects in SUMF1 resulting in the lack of post-translational modification of a highly conserved cysteine into 3-oxoalanine. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.,disease:Defects in ARSA are a cause of leukodystrophy metachromatic (MLD) [MIM:250100]. MLD is a disease due to a lysosomal storage defect. It is characterized by intralysosomal storage of cerebroside-3-sulfate in neural and non-neural tis
Subcellular Location：Endoplasmic reticulum . Lysosome .
Expression： B-cell,Liver,Small intestine,Testis,
