Target：Arnt 2

Fields：Pathways in cancer;Transcriptional misregulation in cancer;Renal cell carcinoma

Gene Name：ARNT2

Protein Name：Aryl hydrocarbon receptor nuclear translocator 2

Human Gene Id：9915

Human Swiss Prot No：Q9HBZ2

Mouse Gene Id：11864

Mouse Swiss Prot No：Q61324

Rat Gene Id：25243

Rat Swiss Prot No：Q78E60

Immunogen：The antiserum was produced against synthesized peptide derived from human ARNT2. AA range:21-70

Specificity：Arnt 2 Polyclonal Antibody detects endogenous levels of Arnt 2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ARNT2;BHLHE1;KIAA0307;Aryl hydrocarbon receptor nuclear translocator 2;ARNT protein 2;Class E basic helix-loop-helix protein 1;bHLHe1

Observed Band(KD)：79kD

Background：aryl hydrocarbon receptor nuclear translocator 2(ARNT2) Homo sapiens This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013],

Function：function:Specifically recognizes the xenobiotic response element (XRE).,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein. Interacts with TACC3.,

Subcellular Location：Nucleus .

Expression： Brain,Human cervix,Spleen,