Target：DRS-1
Fields：Fatty acid degradation;Peroxisome
Gene Name：ECI2
Protein Name：Enoyl-CoA delta isomerase 2 mitochondrial
Human Gene Id：10455
Human Swiss Prot No：O75521
Mouse Swiss Prot No：Q9WUR2
Immunogen：The antiserum was produced against synthesized peptide derived from human PECI. AA range:73-122
Specificity：DRS-1 Polyclonal Antibody detects endogenous levels of DRS-1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ECI2;DRS1;HCA88;PECI;Enoyl-CoA delta isomerase 2; mitochondrial;DRS-1;Delta(3),delta(2)-enoyl-CoA isomerase;D3,D2-enoyl-CoA isomerase;Diazepam-binding inhibitor-related protein 1;DBI-related protein 1;Dodecenoyl-CoA isomerase;Hep
Observed Band(KD)：40kD
Background： This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011],
Function：catalytic activity:(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.,function:Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.,similarity:Contains 1 ACB (acyl-CoA-binding) domain.,similarity:In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.,tissue specificity:Abundant in heart, skeletal muscle and liver.,
Subcellular Location：[Isoform 1]: Mitochondrion .; [Isoform 2]: Peroxisome matrix .
Expression：Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.
