Target：DREG

Gene Name：GPR126

Protein Name：G-protein coupled receptor 126

Human Gene Id：57211

Human Swiss Prot No：Q86SQ4

Mouse Gene Id：215798

Mouse Swiss Prot No：Q6F3F9

Immunogen：The antiserum was produced against synthesized peptide derived from human GPR126. AA range:1091-1140

Specificity：DREG Polyclonal Antibody detects endogenous levels of DREG protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GPR126;DREG;VIGR;G-protein coupled receptor 126;Developmentally regulated G-protein-coupled receptor;Vascular inducible G protein-coupled receptor

Observed Band(KD)：140kD

Background： This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009],

Function：function:Orphan receptor.,polymorphism:Genetic variations in GPR126 influences stature as a quantitative trait (STQTL) [MIM:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 CUB domain.,similarity:Contains 1 GPS domain.,similarity:Contains 1 pentaxin domain.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Detected on the cell surface of activated but not resting umbilical vein. .

Expression：Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.