Target：DRD2

Fields：Rap1 signaling pathway;cAMP signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;Dopaminergic synapse;Parkinson disease;Cocaine addiction;Alcoholism

Gene Name：DRD2

Protein Name：D(2) dopamine receptor (Dopamine D2 receptor)

Human Gene Id：1813

Human Swiss Prot No：P14416

Mouse Swiss Prot No：P61168

Rat Swiss Prot No：P61169

Immunogen：Synthesized peptide derived from human protein . at AA range: 170-250

Specificity：DRD2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：48kD

Background： This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008],

Function：disease:Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.,disease:It has been suggested that DRD2 is involved in psychiatric disorders; especially in schizophrenia.,function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,polymorphism:Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .

Expression：[Isoform 1]: Expressed in the anterior pituitary gland. ; [Isoform 2]: Expressed in the anterior pituitary gland.