Target：DRA

Fields：Pancreatic secretion;Mineral absorption

Gene Name：SLC26A3

Protein Name：Chloride anion exchanger

Human Gene Id：1811

Human Swiss Prot No：P40879

Mouse Gene Id：13487

Mouse Swiss Prot No：Q9WVC8

Rat Gene Id：114629

Rat Swiss Prot No：Q924C9

Immunogen：Synthesized peptide derived from the C-terminal region of human DRA.

Specificity：DRA Polyclonal Antibody detects endogenous levels of DRA protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC26A3;DRA;Chloride anion exchanger;Down-regulated in adenoma;Protein DRA;Solute carrier family 26 member 3

Observed Band(KD)：84kD

Background： The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008],

Function：developmental stage:Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.,disease:Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD) [MIM:214700]. CLD is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.,function:Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 STAS domain.,subunit:Interacts with PDZK1.,

Subcellular Location：Apical cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). .

Expression： Colon,Lung,Rectum tumor,