Target：GCS-α-1

Fields：Purine metabolism;Metabolic pathways;cGMP-PKG signaling pathway;Vascular smooth muscle contraction;Gap junction;Platelet activation;Circadian entrainment;Long-term depression;Oxytocin signaling pathway;Renin secretion;Salivary secretion

Gene Name：GUCY1A3

Protein Name：Guanylate cyclase soluble subunit alpha-3

Human Gene Id：2982

Human Swiss Prot No：Q02108

Mouse Gene Id：60596

Mouse Swiss Prot No：Q9ERL9

Rat Swiss Prot No：P19686

Immunogen：The antiserum was produced against synthesized peptide derived from human GCS-alpha-1. AA range:374-423

Specificity：GCS-α-1 Polyclonal Antibody detects endogenous levels of GCS-α-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GUCY1A3;GUC1A3;GUCSA3;GUCY1A1;Guanylate cyclase soluble subunit alpha-3;GCS-alpha-3;GCS-alpha-1;Soluble guanylate cyclase large subunit

Observed Band(KD)：77kD

Background： Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

Function：catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain.,

Subcellular Location：Cytoplasm .

Expression：Detected in brain cortex and lung (at protein level).