Target：APBA2BP

Gene Name：NECAB3

Protein Name：N-terminal EF-hand calcium-binding protein 3

Human Gene Id：63941

Human Swiss Prot No：Q96P71

Mouse Gene Id：56846

Mouse Swiss Prot No：Q9D6J4

Immunogen：The antiserum was produced against synthesized peptide derived from human NECAB3. AA range:321-370

Specificity：APBA2BP Polyclonal Antibody detects endogenous levels of APBA2BP protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NECAB3;APBA2BP;NIP1;SYTIP2;XB51;N-terminal EF-hand calcium-binding protein 3;Amyloid beta A4 protein-binding family A member 2-binding protein;Nek2-interacting protein 1;Neuronal calcium-binding protein 3;X11L-binding protein 51

Observed Band(KD)：44kD

Background： The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,function:Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid.,PTM:Phosphorylated by NEK2.,similarity:Contains 1 ABM domain.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with the N-terminal domain of APBA2. Interacts with NEK2.,tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas.,

Subcellular Location：Golgi apparatus .

Expression：Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas.