Target：AP-2γ

Gene Name：TFAP2C

Protein Name：Transcription factor AP-2 gamma

Human Gene Id：7022

Human Swiss Prot No：Q92754

Mouse Gene Id：21420

Mouse Swiss Prot No：Q61312

Immunogen：The antiserum was produced against synthesized peptide derived from human AP2C. AA range:401-450

Specificity：AP-2γ Polyclonal Antibody detects endogenous levels of AP-2γ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TFAP2C;Transcription factor AP-2 gamma;AP2-gamma;Activating enhancer-binding protein 2 gamma;Transcription factor ERF-1

Observed Band(KD)：45kD

Background：transcription factor AP-2 gamma(TFAP2C) Homo sapiens The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008],

Function：domain:The WW-binding motif mediates interaction with WWOX.,function:Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.,induction:During retinoic acid-mediated differentiation.,online information:Activatin protein 2 entry,PTM:Sumoylated on Lys-10; which inhibits transcriptional activity.,similarity:Belongs to the AP-2 family.,subunit:Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I

Subcellular Location：Nucleus .

Expression： Liver,Mammary tumor,Ovary,Skin,