Target：DNA pol λ
Fields：Base excision repair;Non-homologous end-joining
Gene Name：POLL
Protein Name：DNA polymerase lambda
Human Gene Id：27343
Human Swiss Prot No：Q9UGP5
Mouse Gene Id：56626
Mouse Swiss Prot No：Q9QXE2
Rat Gene Id：361767
Rat Swiss Prot No：Q5RKI3
Immunogen：The antiserum was produced against synthesized peptide derived from human DNA Polymerase lambda. AA range:451-500
Specificity：DNA pol λ Polyclonal Antibody detects endogenous levels of DNA pol λ protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：POLL;DNA polymerase lambda;Pol Lambda;DNA polymerase beta-2;Pol beta2;DNA polymerase kappa
Observed Band(KD)：63kD
Background： This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010],
Function：catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Manganese.,function:Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA polymerase type-X family.,similarity:Contains 1 BRCT domain.,subunit:Binds PCNA.,tissue specificity:Expressed in a number of tissues. Abundant in testis.,
Subcellular Location：Nucleus . Chromosome . Accumulates at sites of DNA damage. .
Expression：Expressed in a number of tissues. Abundant in testis.
