Target：DOC-1

Gene Name：CDK2AP1

Protein Name：Cyclin-dependent kinase 2-associated protein 1

Human Gene Id：8099

Human Swiss Prot No：O14519

Mouse Gene Id：13445

Mouse Swiss Prot No：O35207

Immunogen：The antiserum was produced against synthesized peptide derived from human CDKAP1. AA range:51-100

Specificity：DOC-1 Polyclonal Antibody detects endogenous levels of DOC-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDK2AP1;CDKAP1;DOC1;Cyclin-dependent kinase 2-associated protein 1;CDK2-associated protein 1;Deleted in oral cancer 1;DOC-1;Putative oral cancer suppressor

Observed Band(KD)：20kD

Background：cyclin dependent kinase 2 associated protein 1(CDK2AP1) Homo sapiens The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],

Function：similarity:Belongs to the CDK2AP family.,

Subcellular Location：nucleus,perinuclear region of cytoplasm,

Expression： Skin,Testis,