Target：DBLOH

Fields：Apoptosis;Apoptosis - multiple species

Gene Name：DIABLO SMAC

Protein Name：Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)

Human Gene Id：56616

Human Swiss Prot No：Q9NR28

Mouse Swiss Prot No：Q9JIQ3

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：DBLOH Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：26kD

Background： This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],

Function：domain:The mature N-terminus mediates interaction with XIAP.,function:Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).,subcellular location:But released into the cytosol when cells undergo apoptosis.,subunit:Interacts with NGFRAP1/BEX3 (By similarity). Homodimer. Interacts with BIRC2, BIRC3, XIAP and BIRC7.,tissue specificity:Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.,

Subcellular Location：Mitochondrion . Released into the cytosol when cells undergo apoptosis.

Expression：Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.