Target：DC1I2

Fields：Phagosome;Vasopressin-regulated water reabsorption;Salmonella infection

Gene Name：DYNC1I2 DNCI2 DNCIC2

Protein Name：Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)

Human Gene Id：1781

Human Swiss Prot No：Q13409

Mouse Swiss Prot No：O88487

Rat Swiss Prot No：Q62871

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：DC1I2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：70kD

Background： This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012],

Function：function:The intermediate chains seem to help dynein bind to dynactin 150 kDa component.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Unlikely isoform. Several sequence problems.,similarity:Belongs to the dynein intermediate chain family.,similarity:Contains 7 WD repeats.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains.,

Subcellular Location：Cytoplasm, cytoskeleton . Cytoplasm . Detected in the cytoplasm of pachytene spermatocytes. Localizes to the manchette in elongating spermatids. .

Expression： Brain,Cajal-Retzius cell,Endometrium,Epithelium,Kidney,Skin