Target：CUX1

Gene Name：CUX1

Protein Name：Homeobox protein cut-like 1/Protein CASP

Human Gene Id：1523

Human Swiss Prot No：P39880/Q13948

Mouse Gene Id：13047/13047

Immunogen：The antiserum was produced against synthesized peptide derived from human CUTL1. AA range:10-59

Specificity：CUX1 Polyclonal Antibody detects endogenous levels of CUX1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CUX1;CUTL1;Homeobox protein cut-like 1;CCAAT displacement protein;CDP;Homeobox protein cux-1;CUX1;CUTL1;Protein CASP

Observed Band(KD)：164kD

Background： The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011],

Function：alternative products:Additional isoforms seem to exist,function:May be involved in intra-Golgi retrograde transport.,function:Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer.,miscellaneous:Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CASP family.,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 homeobox DNA-bin

Subcellular Location：Nucleus .

Expression： Colon,Duodenum,Liver,Umbilical vein,