Target：CUL4A

Fields：Nucleotide excision repair;Ubiquitin mediated proteolysis;Human immunodeficiency virus 1 infection

Gene Name：CUL4A

Protein Name：Cullin-4A (CUL-4A)

Human Gene Id：8451

Human Swiss Prot No：Q13619

Mouse Swiss Prot No：Q3TCH7

Immunogen：Synthesized peptide derived from human protein . at AA range: 590-670

Specificity：CUL4A Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：83kD

Background： CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009],

Function：function:Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(

Subcellular Location：nucleoplasm,cullin-RING ubiquitin ligase complex,Cul4A-RING E3 ubiquitin ligase complex,Cul4-RING E3 ubiquitin ligase complex,

Expression： Lung,