Target：C-TAK1

Gene Name：MARK3

Protein Name：MAP/microtubule affinity-regulating kinase 3

Human Gene Id：4140

Human Swiss Prot No：P27448

Mouse Gene Id：17169

Mouse Swiss Prot No：Q03141

Rat Gene Id：170577

Rat Swiss Prot No：Q8VHF0

Immunogen：The antiserum was produced against synthesized peptide derived from human MARK3. AA range:1-50

Specificity：C-TAK1 Polyclonal Antibody detects endogenous levels of C-TAK1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MARK3;CTAK1;EMK2;MAP/microtubule affinity-regulating kinase 3;C-TAK1;cTAK1;Cdc25C-associated protein kinase 1;ELKL motif kinase 2;EMK-2;Protein kinase STK10;Ser/Thr protein kinase PAR-1;Par-1a;Serine/threonine-protein kinase p78

Observed Band(KD)：85kD

Background：microtubule affinity regulating kinase 3(MARK3) Homo sapiens The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.,similarity:Contains 1 KA1 (kinase-associated) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,tissue specificity:Ubiquitous.,

Subcellular Location：Cell membrane ; Peripheral membrane protein . Cell projection, dendrite . Cytoplasm .

Expression：Ubiquitous.