Target：CREB3

Fields：cGMP-PKG signaling pathway;cAMP signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Longevity regulating pathway;Adrenergic signaling in cardiomyocytes;TNF signaling pathway;Thermogenesis;Cholinergic synapse;Dopaminergic synapse;Insulin secretion;Estrogen signaling pathway;Melanogenesis;Thyroid hormone synthesis;Glucagon signaling pathway;Aldosterone synthesis and secretion;Relaxin signaling pathway;Cortisol synthesis and secretion;Parathyroid hormone synthesis, secretion and action;Insulin resistance;Cushing syndrome;Growth hormone synthesis, secretion and action;Vasopressin-regulated water reabsorption;Huntington disease;Prion disease;Cocaine addiction;Amphetamine addiction;Alcoholism;Hepatitis B;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Viral carcinogenesis;Chemical carcinogenesis - receptor activation;Prostate cancer

Gene Name：CREB3

Protein Name：CREB3

Human Gene Id：10488

Human Swiss Prot No：O43889

Mouse Swiss Prot No：Q61817

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human CREB3. AA range:151-200

Specificity：CREB3 Polyclonal Antibody detects endogenous levels of CREB3

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000, ELISA 1:10000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucin zipper proitein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]

Observed Band(KD)：50kD

Background： This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009],

Function：function:Transcription factors activated upon intramembrane proteolysis (RIP), binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Binds to and requires HCFC1 as a coactivator. Activity and expression are suppressed when the HCFC1-CREB3 complex binds with CREBZF. Participates in LKN-1/CCL15-induced chemotaxis signaling.,PTM:During activation, an approximative 40 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under activation the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Interacts with CCR1. Interacts with HCFC1; required

Subcellular Location：[Isoform 1]: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus . Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (PubMed:10623756). Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC) (PubMed:20546900). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane (PubMed:10623756). .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly in the nucleus (PubMed:19779205). Not associated with membranes (PubMed:19779205). .; [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes w

Expression：Ubiquitously expressed (PubMed:9271389, PubMed:19779205). Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level) (PubMed:20546900).