Target：CREB-2

Fields：MAPK signaling pathway;cGMP-PKG signaling pathway;Mitophagy - animal;Protein processing in endoplasmic reticulum;PI3K-Akt signaling pathway;Apoptosis;Longevity regulating pathway;Adrenergic signaling in cardiomyocytes;TNF signaling pathway;Long-term potentiation;Neurotrophin signaling pathway;Cholinergic synapse;Dopaminergic synapse;Insulin secretion;GnRH signaling pathway;Estrogen signaling pathway;Thyroid hormone synthesis;Glucagon signaling pathway;Aldosterone synthesis and secretion;Relaxin signaling pathway;Cortisol synthesis and secretion;Parathyroid hormone synthesis, secretion and action;Non-alcoholic fatty liver disease;Cushing syndrome;Growth hormone synthesis, secretion and action;Alzheimer disease;Parkinson disease;Amyotrophic lateral sclerosis;Prion disease;Pathways of neurodegeneration - multiple diseases;Cocaine addiction;Amphetamine addiction;Alcoholism;Hepatitis B;Human cytomegalovirus infection;Hu

Gene Name：ATF4

Protein Name：Cyclic AMP-dependent transcription factor ATF-4

Human Gene Id：468

Human Swiss Prot No：P18848

Mouse Gene Id：11911

Mouse Swiss Prot No：Q06507

Immunogen：Synthesized peptide derived from CREB-2 . at AA range: 160-240

Specificity：CREB-2 Polyclonal Antibody detects endogenous levels of CREB-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ATF4;CREB2;TXREB;Cyclic AMP-dependent transcription factor ATF-4;cAMP-dependent transcription factor ATF-4;Activating transcription factor 4;Cyclic AMP-responsive element-binding protein 2;CREB-2;cAMP-responsive element-binding prot

Observed Band(KD)：38kD

Background：activating transcription factor 4(ATF4) Homo sapiens This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provid

Function：function:Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subcellular location:Colocalizes with GABBR1 in hippocampal neuron dendritic membranes.,subunit:Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Binds DNA as a homo-or heterodimer. Interacts with the N-terminal region of CEP290.,

Subcellular Location：Nucleus . Nucleus speckle . Cytoplasm . Cell membrane . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772). .

Expression： Bladder,Colon,Fibroblast,Leukemic T-cell,Lung,Ovary,Placenta,