Target：KLF8
Gene Name：KLF8
Protein Name：Krueppel-like factor 8
Human Gene Id：11279
Human Swiss Prot No：O95600
Mouse Swiss Prot No：Q8BLM0
Immunogen：The antiserum was produced against synthesized peptide derived from human KLF8. AA range:191-240
Specificity：KLF8 Polyclonal Antibody detects endogenous levels of KLF8 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：KLF8;BKLF3;ZNF741;Krueppel-like factor 8;Basic krueppel-like factor 3;Zinc finger protein 741
Molecular Weight(Da)：39kD
Background： This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
Function：function:Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).,PTM:Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8.,tissue specificity:Ubiquitous.,
Subcellular Location：Nucleus .
Expression：Ubiquitous.
