Target：KPI-2

Gene Name：LMTK2

Protein Name：Serine/threonine-protein kinase LMTK2

Human Gene Id：22853

Human Swiss Prot No：Q8IWU2

Mouse Swiss Prot No：Q3TYD6

Immunogen：The antiserum was produced against synthesized peptide derived from human LMTK2. AA range:651-700

Specificity：KPI-2 Polyclonal Antibody detects endogenous levels of KPI-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LMTK2;AATYK2;BREK;KIAA1079;KPI2;LMR2;Serine/threonine-protein kinase LMTK2;Apoptosis-associated tyrosine kinase 2;Brain-enriched kinase;hBREK;CDK5/p35-regulated kinase;CPRK;Kinase/phosphatase/inhibitor 2;Lemur tyrosine kinase 2

Observed Band(KD)：164kD

Background： The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates PPP1C, phosphorylase b and CFTR.,online information:LMTK2 entry,PTM:Autophosphorylated. Phosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PPP1C and inhibitor-2.,tissue specificity:Mainly expressed in skeletal muscle, and weakly in brain and pancreas.,

Subcellular Location：Membrane ; Multi-pass membrane protein .

Expression：Mainly expressed in skeletal muscle, and weakly in brain and pancreas.