Target：KLF7

Gene Name：KLF7

Protein Name：Krueppel-like factor 7

Human Gene Id：8609

Human Swiss Prot No：O75840

Mouse Gene Id：93691

Mouse Swiss Prot No：Q99JB0

Immunogen：The antiserum was produced against synthesized peptide derived from human KLF7. AA range:171-220

Specificity：KLF7 Polyclonal Antibody detects endogenous levels of KLF7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KLF7;UKLF;Krueppel-like factor 7;Ubiquitous krueppel-like factor

Observed Band(KD)：41kD

Background： The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

Function：domain:The acidic N-terminal part may favor interaction with the basic domain of transcription factors.,function:Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo.,

Subcellular Location：Nucleus .

Expression：Widely expressed.