Target：NLRX1

Fields：NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Influenza A

Gene Name：NLRX1

Protein Name：NLRX1

Human Gene Id：79671

Human Swiss Prot No：Q86UT6

Mouse Gene Id：270151

Mouse Swiss Prot No：Q3TL44

Rat Swiss Prot No：Q5FVQ8

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human NLRX1. AA range:581-630

Specificity：NLRX1 Polyclonal Antibody detects endogenous levels of NLRX1

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NLR family member X1 (Caterpiller protein 11.3;CLR11.3;Nucleotide-binding oligomerization domain protein 26;Nucleotide-binding oligomerization domain protein 5;Nucleotide-binding oligomerization domain protein 9)

Observed Band(KD)：108kD

Background： The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013],

Function：function:Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).,sequence caution:Translated as Trp.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the NLRP family.,similarity:Contains 1 NACHT domain.,similarity:Contains 4 LRR (leucine-rich) repeats.,subunit:Interacts with MAVS.,tissue specificity:Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).,

Subcellular Location：Mitochondrion outer membrane .

Expression：Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).