Target：NK-1R

Fields：Calcium signaling pathway;Neuroactive ligand-receptor interaction

Gene Name：TACR1

Protein Name：Substance-P receptor

Human Gene Id：6869

Human Swiss Prot No：P25103

Mouse Gene Id：21336

Mouse Swiss Prot No：P30548

Rat Gene Id：24807

Rat Swiss Prot No：P14600

Immunogen：The antiserum was produced against synthesized peptide derived from human NK1R. AA range:211-260

Specificity：NK-1R Polyclonal Antibody detects endogenous levels of NK-1R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TACR1;NK1R;TAC1R;Substance-P receptor;SPR;NK-1 receptor;NK-1R;Tachykinin receptor 1

Observed Band(KD)：50kD

Background： This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008],

Function：function:This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.,online information:Tachykinin entry,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression： Brain,G-protein coupled receptors,Lung,Placenta,