Target：NK-2R

Fields：Calcium signaling pathway;Neuroactive ligand-receptor interaction

Gene Name：TACR2

Protein Name：Substance-K receptor

Human Gene Id：6865

Human Swiss Prot No：P21452

Mouse Swiss Prot No：P30549

Immunogen：The antiserum was produced against synthesized peptide derived from human NK2R. AA range:301-350

Specificity：NK-2R Polyclonal Antibody detects endogenous levels of NK-2R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TACR2;NK2R;NKNAR;TAC2R;Substance-K receptor;SKR;NK-2 receptor;NK-2R;Neurokinin A receptor;Tachykinin receptor 2

Observed Band(KD)：48kD

Background： This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008],

Function：function:This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.,miscellaneous:The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression： Bone marrow,Lung,Stomach,Trachea,