Target：Palladin

Gene Name：PALLD

Protein Name：Palladin

Human Gene Id：23022

Human Swiss Prot No：Q8WX93

Mouse Swiss Prot No：Q9ET54

Immunogen：Synthesized peptide derived from Palladin . at AA range: 450-530

Specificity：Palladin Polyclonal Antibody detects endogenous levels of Palladin protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PALLD;KIAA0992;CGI-151;Palladin;SIH002;Sarcoma antigen NY-SAR-77

Observed Band(KD)：150kD

Background： This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

Function：caution:Was wrongly assigned as myoneurin (Ref.2).,disease:Genetic variations in PALLD are associated with susceptibility to pancreatic cancer type 1 (PNCA1) [MIM:606856]. Expression is increased early in the development of pancreatic cancer: in normal-appearing whole tissue immediately adjacent to cancer, in the pre-cancer, and in both the familial and sporadic forms of the cancer.,disease:Genetic variations in PALLD may be associated with myocardial infarction.,function:Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monome

Subcellular Location：Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, ruffle . Cell projection, podosome . Cell projection, lamellipodium . Cell projection, axon . Cell projection, growth cone . Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434). Preferentially expressed in the excitatory presynaptic terminals (By similarity). .

Expression：Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines.